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When the Alt-R™ HDR Donor Blocks are incorporated via the homology-directed repair (HDR) pathway, we have not observed evidence of integration of the universal terminal sequences, or modifications. The modification reduces unwanted non-homologous insertion (blunt integration) events. However, if undesired blunt integration does occur then the universal terminal sequences may be integrated into the genome along with the donor template, but that would be considered a rare event.